Epilepsy; Language; Magnetic Resonance Imaging; Memory; Neurology; Neurosurgery; Vision, Ocular
Neurology: Clinical Neurosciences Imaging Center
If treatment with medication is not successful, neurosurgery is potentially curative for patients with epilepsy. The ability of these patients to proceed to surgery rests on the surgical team being able to accurately evaluate the likely benefit of surgery, however. A critical component of this evaluation is determining whether surgery could pose any risk to language. While we can identify which half of the brain is critical to language, we do not yet have simple methods for mapping the specific parts important for language within a given hemisphere. My work is currently determining whether a new method is suitable for doing this. We are currently finishing a study of the method’s reliability, and are developing work determining it's validity. We hope this will lead to a new method neuropsychologists and epilepsy teams can use to make sure patients and clinicians have the best information at hand in decision making.
Specialized Terms: Epilepsy, MRI, fMRI, DWI, Language, Memory, Vision
Extensive Research Description
There are currently options for junior researchers to work on the below and related projects.
• Reliability of a novel approach to presurgical language localization. In this study I am examining the reliability of a method of language localization in epilepsy using fMRI. This method is novel as it relies upon a clinician with particular knowledge of the brain's language network, cognition and fMRI to analyze the data. The study is funded by the National Academy of Neuropsychology.
• Validity of a novel method of presurgical language localization. In a related study I am examining the validity of this method by comparing language maps generated by clinicians with separate measures of patients' language function.
• Reliability of a novel approach to presurgical language localization.
• Validity of a novel method of presurgical language localization.
Optimization of tractography of the optic radiations
Optimization of tractography of the optic radiations. Benjamin CF1, Singh JM, Prabhu SP, Warfield SK.Hum Brain Mapp. 2014 Feb;35(2):683-97. doi: 10.1002/hbm.22204. Epub 2012 Dec 8.
Elemental spatial and temporal association formation in left temporal lobe epilepsy
Elemental spatial and temporal association formation in left temporal lobe epilepsy. Benjamin CF1, Saling MM2, Wood AG3, Reutens DC4. PLoS One. 2014 Jun 30;9(6):e100891. doi: 10.1371/journal.pone.0100891. eCollection 2014.
Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases
Połczyńska MM1, Benjamin CF, Moseley BD, Walshaw P, Eliashiv D, Vigil C, Jones M, Bookheimer SY. Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases. Neurocase. 2015;21(6):707-20. doi: 10.1080/13554794.2014.977300. Epub 2014 Nov 5.
Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network.
Grammar tests increase the ability to lateralize language function in the Wada test.
Epilepsy Res. 2014 Dec;108(10):1864-73
The influence of rest period instructions on the default mode network
Benjamin C1, Lieberman DA, Chang M, Ofen N, Whitfield-Gabrieli S, Gabrieli JD, Gaab N. The influence of rest period instructions on the default mode network. Front Hum Neurosci. 2010 Dec 1;4:218. doi: 10.3389/fnhum.2010.00218. eCollection 2010.
What's the story? The tale of reading fluency told at speed.
Benjamin CF1, Gaab N. What's the story? The tale of reading fluency told at speed. Hum Brain Mapp. 2012 Nov;33(11):2572-85. doi: 10.1002/hbm.21384. Epub 2011 Sep 23.
Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy.
Wood AG1, Saling MM, Fedi M, Berkovic SF, Scheffer IE, Benjamin C, Reutens DC. Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy Behav. 2010 Apr;17(4):531-5. doi: 10.1016/j.yebeh.2010.01.168. Epub 2010 Feb 26.
Full List of PubMed Publications
- Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY: Presurgical language fMRI: Mapping of six critical regions. Hum Brain Mapp. 2017 Aug; 2017 May 23. PMID: 28544168
- Połczyńska M, Japardi K, Curtiss S, Moody T, Benjamin C, Cho A, Vigil C, Kuhn T, Jones M, Bookheimer S: Improving language mapping in clinical fMRI through assessment of grammar. Neuroimage Clin. 2017; 2017 May 26. PMID: 28616382
- Połczyńska MM, Benjamin CF, Japardi K, Frew A, Bookheimer SY: Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network. Neuropsychologia. 2016 Jun; 2016 Apr 30. PMID: 27143224