Dennis Dee Spencer MD

Harvey and Kate Cushing Professor of Neurosurgery; Chair, Department of Neurosurgery; Director, Epilepsy Surgery Program; Director, Pituitary Tumor Program

Research Interests

Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, Microdialysis, and human tissue studies

Research Summary

Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.

Selected Publications

  • Eid T, Hammer J, Runden-Pran E, Roberg B, Thomas MJ, Osen K. Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Otterson OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathol (Berl) 113(2):137-52, 2007.
  • DeLorenzo C, Papademetris X, WuK, Vives KP, Spencer D, Duncan JS. Nonrigid 3D brain registration using intensity/feature information. Med Image Comput Comput Assist Interv Int Conf 9(Pt1):932-9, 2006.
  • Malthankar-Phatak GH, de Lanerolle NC, Eid T, Spencer DD, Behar KL, Spencer SS, KimJH, Lai JCK. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 47(8):1292-1299, 2006.

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