Long-Term Outcome of Epilepsy Surgery

This project is a prospective multimodal outcome study funded by NIH and based at Yale which includes 6 other sites, and follows the seizure, quality of life, cognitive and psychiatric outcomes of resective epilepsy surgery with standard interventions and instruments to measure those aspects of patient response. Ongoing analyses will focus on the interplay between these outcomes, predictors of outcomes, differences in procedures involving various cerebral locations, and other questions that can be addressed using this remarkable database. Individual diagnostic methods, for example MRI with standardized interpretation, or SPECT with ictal injection and co-registration and subtraction processing are part of the diagnostic evaluation, and their interpretation, interrater reliability, correlation with other localizing studies, and predictive value for pathology and outcome can be examined in this large contemporary surgical population.