Xenophon Papademetris, PhD

Associate Professor of Diagnostic Radiology and of Biomedical Engineering

Research Organizations

Diagnostic Radiology: Bioimaging Sciences: BioImage Suite; Image Processing & Analysis Group; Magnetic Resonance Research Center | Quantitative Neuroscience with Magnetic Resonance

Discovery to Cure Internship

Yale Translational Research Imaging Center (Y-TRIC)

Research Summary

Dr. Xenophon Papademetris's research is currently focused on three main areas: (i) brain deformation modeling and compensation during neurosurgical interventions, as well as complex 3D visualization of multimodal image data for surgical planning and guidance; (ii) Medical Image Analysis software development – primarily the BioImage Suite project (see www.bioimagesuite.org); and (iii) vascular image analysis, both in terms of monitoring angiogenesis and in the quantification of the growth of tissue engineered vessels.

Selected Publications

  • A non-parametric vessel detection method for complex vascular structures. Qian X, Brennan MP, Dione DP, Dobrucki WL, Jackowski MP, Breuer CK, Sinusas AJ, Papademetris X. Med Image Anal. 2009 Feb;13(1):49-61. Epub 2008 Jun 14. PMID: 18678521 [
  • Effective visualization of complex vascular structures using a non-parametric vessel detection method. Joshi A, Qian X, Dione DP, Bulsara KR, Breuer CK, Sinusas AJ, Papademetris X. IEEE Trans Vis Comput Graph. 2008 Nov-Dec;14(6):1603-10. PMID: 18989016
  • From medical image computing to computer-aided intervention: development of a research interface for image-guided navigation. Papademetris X, DeLorenzo C, Flossmann S, Neff M, Vives KP, Spencer DD, Staib LH, Duncan JS. Int J Med Robot. 2009 Jun;5(2):147-5
  • Shape Comparison Using Perturbing Shape Registration. Jiang Y, Edmiston E, Wang F, Blumberg HP, Staib LH, Papademetris X. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit. 2009 Jun 20;2009:683-690. PMID: 20386618 [PubMed]
  • A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging. Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X. Med Image Anal. 2011 Feb;15(1):96-111. Epub 2010 Sep 24.
  • Unified framework for development, deployment and robust testing of neuroimaging algorithms. Joshi A, Scheinost D, Okuda H, Belhachemi D, Murphy I, Staib LH, Papademetris X. Neuroinformatics. 2011 Mar;9(1):69-84.
  • Vascular Tree Reconstruction by Minimizing A Physiological Functional Cost. Jiang Y, Zhuang Z, Sinusas AJ, Papademetris X. Conf Comput Vis Pattern Recognit Workshops. 2010 Jun 13:178-185.

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Contact Info

Xenophon Papademetris, PhD
Mailing Address
Diagnostic RadiologyPO Box 208043
TAC N119

New Haven, CT 06520-8043

BioImage Suite Project